Author/Authors :
Bola?os-Jiméneza، R نويسنده Neuroscience and Biotechnology Laboratory, School of Medicine, Universidad Panamericana, México DF, México. , , Escamilla-Oca?as، C نويسنده Tisular Engineering and Regenerative Medicine Laboratory, University of Monterrey, San Pedro Garza Garc?a, NL, México. , , Mart?nez-Menchaca، H نويسنده Tisular Engineering and Regenerative Medicine Laboratory, University of Monterrey, San Pedro Garza Garc?a, NL, México. , , Rivera-Silva، G نويسنده Tisular Engineering and Regenerative Medicine Laboratory, University of Monterrey, San Pedro Garza Garc?a, NL, México. , , Chacon-Camacho، O F نويسنده Department of Genetics-Research Unit, Institute of Ophthalmology “Conde de Valenciana” Mexico City, Mexico. , , Carrillo-Ru?z، J D نويسنده Neurosurgery Clinic of Spasticity, Service Functional Neurosurgery and Radiosurgery Hospital General de México O.D. ,
Abstract :
The loss of dopaminergic neurons in the substancia nigra pars compacta leads to the characteristic symptoms of Parkinsonʹs disease (PD), whose Lewy bodies is a pathologic sign almost always found. Various monogenic forms account for a minority of cases of PD, but have provided crucial insight into disease mechanism. However, genetically faithful models have not been exposed to putative toxicants in a manner that is clearly relevant to human exposures, and most of studies have used conventional genetically modified animals and convenient dosing paradigms. Better translation between preclinical, neuropathologic animal model and, clinical research would be important for future clinical trials.
