Nephrosterinic acid inhibits the growth of murine malignant pleural sarcoma cells in vitro

We test the effects of Nephrosterinic acid, secondary metabolite of the lichen Solenospora liparina, on the growth of murine malignant pleural sarcoma cells in vitro. We find that Nephrosterinic acid is a potent inhibitor of growth. We also find that Nephrosterinic acid increases sensitivity of cells to radiation, and this effect is significant at radiation intensity lower than the standard intensity of cancer radiotherapy. On the basis of this study, Nephrosterinic acid shows promise for combined-modality cancer treatment