Title of article
Functional polyethylene glycol derivatives nanostructured thin films synthesized by matrix-assisted pulsed laser evaporation
Author/Authors
R. Cristescu، نويسنده , , C. Popescu، نويسنده , , Bogdan A. Popescu، نويسنده , , S. Grigorescu، نويسنده , , Shyh-Lin Tsao and I.N. Mihailescu، نويسنده , , D. Mihaiescu and A. Moldovan، نويسنده , , S.D. Gittard، نويسنده , , R.J. Narayan، نويسنده , , T. Buruiana، نويسنده , , I. Stamatin، نويسنده , , D.B. Chrisey، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
4
From page
9873
To page
9876
Abstract
We report the thin film deposition by matrix-assisted pulsed laser evaporation (MAPLE) of a polymer conjugate with an hydrophilic sequence between metronidazole molecules that was covalently attached to both oligomer ends of carboxylate poly(ethylene glycol) (PEG 1.5–metronidazole). A pulsed KrF* excimer laser was used to deposit the drug–polymer composite films. Fourier transform infrared spectroscopy was used to demonstrate that MAPLE-transferred materials exhibited chemical properties similar to the starting materials. The dependence of the surface morphology on incident laser fluence is given.
Keywords
Metronidazole , Drug delivery , Poly(ethylene glycol) , Matrix-assisted pulsed laser evaporation
Journal title
Applied Surface Science
Serial Year
2009
Journal title
Applied Surface Science
Record number
1012368
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