Author/Authors :
R. Cristescu، نويسنده , , C. Popescu، نويسنده , , Bogdan A. Popescu، نويسنده , , S. Grigorescu، نويسنده , , Shyh-Lin Tsao and I.N. Mihailescu، نويسنده , , D. Mihaiescu and A. Moldovan، نويسنده , , S.D. Gittard، نويسنده , , R.J. Narayan، نويسنده , , T. Buruiana، نويسنده , , I. Stamatin، نويسنده , , D.B. Chrisey، نويسنده ,
Abstract :
We report the thin film deposition by matrix-assisted pulsed laser evaporation (MAPLE) of a polymer conjugate with an hydrophilic sequence between metronidazole molecules that was covalently attached to both oligomer ends of carboxylate poly(ethylene glycol) (PEG 1.5–metronidazole). A pulsed KrF* excimer laser was used to deposit the drug–polymer composite films. Fourier transform infrared spectroscopy was used to demonstrate that MAPLE-transferred materials exhibited chemical properties similar to the starting materials. The dependence of the surface morphology on incident laser fluence is given.
Keywords :
Metronidazole , Drug delivery , Poly(ethylene glycol) , Matrix-assisted pulsed laser evaporation
