Author/Authors :
Siva Reddy، Y. V. نويسنده , , Jeffrey Bose، N.J نويسنده Research Department of Botany, V.H.N.Senthikumara Nadar College, Virudhunagar, Tamil Nadu, India. Phone: 04562-280154 Fax: 04562-281338. , , Mehalingam، P. نويسنده Research Centre in Botany, V.H.N. Senthikumara Nadar College, Virudhunagar, Tamil Nadu India. , , Thanga Thirupathi، A. نويسنده Department of Pharmacology, SankaralingamBhuvaneswari College of Pharmacy, Sivakasi, Tamil Nadu, India. ,
Abstract :
The aqueous and ethanolic extracts of Pedalium murex (Pedaliaceae)
was investigated for antipyretic activity in rats using Brewer’s yeast-induced
pyrexia models. Brewer’s yeast (15%) was used to induce pyrexia in rats. Both
the extract (200 and 400 mg/kg body weight p.o produced a significant
(p < 0.05) dose dependent inhibition of temperature elevation compared with
the standard drug Paracetamol (150mg/kg body weight). At doses of 200
mg/kg b.w, the aqueous extract significantly (P < 0.001) decreased yeast induced
pyrexia in rats. These results indicate that leaf extracts of Pedalium murex
possesses potent antipyretic effects and thus pharmacologically justifying its
folkloric use in the management of fever.
