Title of article :
Axonal Remodeling and Synaptic Differentiation in the Cerebellum Is Regulated by WNT-7a Signaling
Author/Authors :
Anita C Hall، نويسنده , , Fiona S. Lucas، نويسنده , , Patricia Oidor-Salinas ، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Pages :
11
From page :
525
To page :
535
Abstract :
Synapse formation requires changes in cell morphology and the upregulation and localization of synaptic proteins. In the cerebellum, mossy fibers undergo extensive remodeling as they contact several granule cells and form complex, multisynaptic glomerular rosettes. Here we show that granule cells secrete factors that induce axon and growth cone remodeling in mossy fibers. This effect is blocked by the WNT antagonist, sFRP-1, and mimicked by WNT-7a, which is expressed by granule cells. WNT-7a also induces synapsin I clustering at remodeled areas of mossy fibers, a preliminary step in synaptogenesis. Wnt-7a mutant mice show a delay in the morphological maturation of glomerular rosettes and in the accumulation of synapsin I. We propose that WNT-7a can function as a synaptogenic factor.
Journal title :
CELL
Serial Year :
2000
Journal title :
CELL
Record number :
1016894
Link To Document :
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