Title of article :
Squeezing Axons Out of the Gray Matter: A Role for Slit and Semaphorin Proteins from Midline and Ventral Spinal Cord
Author/Authors :
Yimin Zou، نويسنده , , Esther Stoeckli، نويسنده , , Hang Chen، نويسنده , , Marc Tessier-Lavigne، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Pages :
13
From page :
363
To page :
375
Abstract :
Commissural axons cross the nervous system midline and then turn to grow alongside it, neither recrossing nor projecting back into ventral regions. In Drosophila, the midline repellent Slit prevents recrossing: axons cross once because they are initially unresponsive to Slit, becoming responsive only upon crossing. We show that commissural axons in mammals similarly acquire responsiveness to a midline repellent activity upon crossing. Remarkably, they also become responsive to a repellent activity from ventral spinal cord, helping explain why they never reenter that region. Several Slit and Semaphorin proteins, expressed in midline and/or ventral tissues, mimic these repellent activities, and midline guidance defects are observed in mice lacking neuropilin-2, a Semaphorin receptor . Thus, Slit and Semaphorin repellents from midline and nonmidline tissues may help prevent crossing axons from reentering gray matter, squeezing them into surrounding fiber tracts.
Journal title :
CELL
Serial Year :
2000
Journal title :
CELL
Record number :
1017058
Link To Document :
بازگشت