Title of article :
SNARE Complex Oligomerization by Synaphin/Complexin Is Essential for Synaptic Vesicle Exocytosis
Author/Authors :
Hiroshi Tokumaru، نويسنده , , Keiko Umayahara، نويسنده , , Lorenzo L Pellegrini، نويسنده , , Toru Ishizuka، نويسنده , , Hideo Saisu، نويسنده , , Heinrich Betz and Winfried Weissenhorn، نويسنده , , George J Augustine، نويسنده , , Teruo Abe، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Pages :
12
From page :
421
To page :
432
Abstract :
Synaphin/complexin is a cytosolic protein that preferentially binds to syntaxin within the SNARE complex. We find that synaphin promotes SNAREs to form precomplexes that oligomerize into higher order structures. A peptide from the central, syntaxin binding domain of synaphin competitively inhibits these two proteins from interacting and prevents SNARE complexes from oligomerizing. Injection of this peptide into squid giant presynaptic terminals inhibited neurotransmitter release at a late prefusion step of synaptic vesicle exocytosis. We propose that oligomerization of SNARE complexes into a higher order structure creates a SNARE scaffold for efficient, regulated fusion of synaptic vesicles.
Journal title :
CELL
Serial Year :
2001
Journal title :
CELL
Record number :
1017274
Link To Document :
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