Title of article :
BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function
Author/Authors :
Sharon B. Cantor، نويسنده , , Daphne W. Bell، نويسنده , , Shridar Ganesan، نويسنده , , Elizabeth M. Kass، نويسنده , , Ronny Drapkin، نويسنده , , Steven Grossman، نويسنده , , Doke C.R. Wahrer، نويسنده , , Dennis C. Sgroi، نويسنده , , William S. Lane، نويسنده , , Daniel A. Haber، نويسنده , , David M. Livingston، نويسنده ,
Abstract :
BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase family. BACH1 binds directly to the BRCT repeats of BRCA1. A BACH1 derivative, bearing a mutation in a residue that was essential for catalytic function in other helicases, interfered with normal double-strand break repair in a manner that was dependent on its BRCA1 binding function. Thus, BACH1/BRCA1 complex formation contributes to a key BRCA1 activity. In addition, germline BACH1 mutations affecting the helicase domain were detected in two early-onset breast cancer patients and not in 200 matched controls. Thus, it is conceivable that, like BRCA1, BACH1 is a target of germline cancer-inducing mutations.
