Title of article :
Nuclear Envelope Breakdown Proceeds by Microtubule-Induced Tearing of the Lamina
Author/Authors :
Joël Beaudouin، نويسنده , , Daniel Gerlich، نويسنده , , Nathalie Daigle، نويسنده , , Roland Eils، نويسنده , , Jan Ellenberg، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Pages :
14
From page :
83
To page :
96
Abstract :
The mechanism of nuclear envelope breakdown (NEBD) was investigated in live cells. Early spindle microtubules caused folds and invaginations in the NE up to one hour prior to NEBD, creating mechanical tension in the nuclear lamina. The first gap in the NE appeared before lamin B depolymerization, at the site of maximal tension, by a tearing mechanism. Gap formation relaxed this tension and dramatically accelerated the rate of chromosome condensation. The hole produced in the NE then rapidly expanded over the nuclear surface. NE fragments remaining on chromosomes were removed toward the centrosomes in a microtubule-dependent manner, suggesting a mechanism mediated by a minus-end-directed motor.
Journal title :
CELL
Serial Year :
2002
Journal title :
CELL
Record number :
1017638
Link To Document :
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