Title of article :
Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan
Author/Authors :
Nataliya Libina، نويسنده , , Jennifer R. Berman، نويسنده , , Cynthia Kenyon، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Pages :
14
From page :
489
To page :
502
Abstract :
In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced insulin/IGF-1 signaling or germline ablation. In this study, we have asked how different tissues interact to specify the lifespan of the animal. We find that several tissues act as signaling centers. In particular, DAF-16 activity in the intestine, which is also the animalʹs adipose tissue, completely restores the longevity of daf-16(−) germline-deficient animals, and increases the lifespans of daf-16(−) insulin/IGF-1-pathway mutants substantially. Our findings indicate that DAF-16 may control two types of downstream signals: DAF-16 activity in signaling cells upregulates DAF-16 in specific responding tissues, possibly via regulation of insulin-like peptides, and also evokes DAF-16-independent responses. We suggest that this network of tissue interactions and feedback regulation allows the tissues to equilibrate and fine-tune their expression of downstream genes, which, in turn, coordinates their rates of aging within the animal.
Journal title :
CELL
Serial Year :
2003
Journal title :
CELL
Record number :
1018426
Link To Document :
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