Author/Authors :
Mohammadi Ziarani، G نويسنده Department of Chemistry, Alzahra University, Tehran, Iran , , Hosseini Mohtasham، N نويسنده Department of Chemistry, Alzahra University, Tehran, Iran , , Lashgari، N نويسنده Department of Chemistry, Alzahra University, Tehran, Iran, School of Chemistry, College of Science, University of Tehran, Tehran, Iran , , Badiei، A نويسنده School of Chemistry, College of Science, University of Tehran, Tehran, Iran , , Amanlou، M نويسنده Drug Design and Development Research Center and Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , , Bazl، R نويسنده Drug Design and Development Research Center and Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran ,
Abstract :
سنتز ساده و كارامد سه جزيي پيران مهم زيستي توسط واكنش isatin، معرف متيلن فعال، و 4-هيدروكسي كوماريندر محيط آبي انجام شد. SBA-PR-NH2 به كاتاليزور اساسي جامد نانوحفره ناهمگن كارآمد (اندازه منافذ از 6 نانومتر) كه مي تواند به راحتي به كار گرفته و از مخلوط واكنش توسط فيلتراسيون ساده حذف شود، ايجاد شده است. اين روش ارزش هاي بزرگ به دليل ماهيت خود سازگار با محيط زيست، پردازش عملكرد بالا، و حمل و نقل آسان دارد. فعاليت هاي بيولوژيكي تركيبات هدف با ارزيابي مهار آنزيم اوره خود به نمايش درآمده اند.
Abstract :
A simple and efficient one-pot three-component synthesis of the
biologically important spirooxindole-4H-pyrans was carried out by
the reaction of isatin, activated methylene reagents, and 4-
hydroxycoumarin in aqueous medium. SBA-Pr-NH2 was found to be
an efficient heterogeneous nanoporous solid basic catalyst (pore size
of 6 nm) which can be easily handled and removed from the reaction
mixture by simple filtration. This method is of great value because
of its environmentally benign character, high yield processing, and
easy handling. The biological activity of target compounds was
screened by evaluation of their urease enzyme inhibition.
