Title of article
Phosphoinositides Specify Polarity during Epithelial Organ Development
Author/Authors
Frank I. Comer، نويسنده , , Carole A. Parent، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
2
From page
239
To page
240
Abstract
The molecular mechanisms that integrate cellular polarity with tissue architecture during epithelial morphogenesis are poorly understood. Using a three-dimensional model of epithelial morphogenesis, report that the phosphatase PTEN and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] regulate the GTPase Cdc42 and the kinase aPKC to generate the apical plasma membrane domain and maintain apical-basolateral polarity.
Journal title
CELL
Serial Year
2007
Journal title
CELL
Record number
1018502
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