Title of article :
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
Author/Authors :
Robert J. Klose، نويسنده , , Qin Yan، نويسنده , , Zuzana Tothova، نويسنده , , Kenichi Yamane، نويسنده , , Hediye Erdjument-Bromage، نويسنده , , Paul Tempst، نويسنده , , D. Gary Gilliland، نويسنده , , Yi Zhang، نويسنده , , William G. Kaelin Jr.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Pages :
12
From page :
889
To page :
900
Abstract :
Changes in histone methylation status regulate chromatin structure and DNA-dependent processes such as transcription. Recent studies indicate that, analogous to other histone modifications, histone methylation is reversible. Retinoblastoma binding protein 2 (RBP2), a nuclear protein implicated in the regulation of transcription and differentiation by the retinoblastoma tumor suppressor protein, contains a JmjC domain recently defined as a histone demethylase signature motif. Here we report that RBP2 is a demethylase that specifically catalyzes demethylation on H3K4, whose methylation is normally associated with transcriptionally active genes. RBP2−/− mouse cells displayed enhanced transcription of certain cytokine genes, which, in the case of SDF1, was associated with increased H3K4 trimethylation. Furthermore, RBP2 specifically demethylated H3K4 in biochemical and cell-based assays. These studies provide mechanistic insights into transcriptional regulation by RBP2 and provide the first example of a mammalian enzyme capable of erasing trimethylated H3K4.
Journal title :
CELL
Serial Year :
2007
Journal title :
CELL
Record number :
1018565
Link To Document :
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