Title of article
A Fight for Neurotransmission: SCRAPPER Trashes RIM
Author/Authors
Frederick Dobie، نويسنده , , Ann Marie Craig، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
3
From page
775
To page
777
Abstract
The presynaptic scaffold molecule RIM1α is important for regulating neurotransmitter release. In this issue, show in mice that an E3 ubiquitin ligase, SCRAPPER, targets a set of presynaptic proteins including RIM1α for degradation by the ubiquitin-proteasome system. Their results identify protein degradation as a mechanism for holding rapid synaptic communication in check.
Journal title
CELL
Serial Year
2007
Journal title
CELL
Record number
1018821
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