Title of article :
A Fight for Neurotransmission: SCRAPPER Trashes RIM
Author/Authors :
Frederick Dobie، نويسنده , , Ann Marie Craig، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
The presynaptic scaffold molecule RIM1α is important for regulating neurotransmitter release. In this issue, show in mice that an E3 ubiquitin ligase, SCRAPPER, targets a set of presynaptic proteins including RIM1α for degradation by the ubiquitin-proteasome system. Their results identify protein degradation as a mechanism for holding rapid synaptic communication in check.
