Title of article :
Retrovirus Silencing by an Epigenetic TRIM
Author/Authors :
James Ellis، نويسنده , , Akitsu Hotta، نويسنده , , Mojgan Rastegar، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
Embryonic cells silence transcription by retroviruses, but how do they recognize virus DNA? In this issue, report that a TRIM28 corepressor complex binds to the retrovirus primer binding site. Epigenetic silencing of retrovirus transcription is accomplished by “writing” a dimethyl mark on lysine 9 of histone H3 that is read by the heterochromatin protein HP1γ.
