Gaucher Disease: Forging a New Path to the Lysosome

Most lysosomal proteins are tagged with a carbohydrate modification that allows their recognition and transport to the lysosome. In this issue, identify a new pathway for protein sorting to the lysosome. They show that β-glucocerebrosidase—the lysosomal enzyme defective in patients with Gaucher disease—is delivered to the lysosome through its interaction with the transmembrane protein LIMP-2.