Author/Authors :
Holm Zaehres، نويسنده , , Hans R. Sch?ler، نويسنده ,
Abstract :
In this issue of Cell, transfer their seminal work on somatic cell reprogramming from the mouse to human. By overexpressing the transcription factor quartet of Oct4, Sox2, Klf4, and c-Myc in adult human fibroblasts, they successfully isolate human pluripotent stem cells that resemble human embryonic stem cells by all measured criteria. This is a significant turning point in nuclear reprogramming research with broad implications for generating patient-specific pluripotent stem cells for research and therapeutic applications.
