Title of article
Tenets of PTEN Tumor Suppression
Author/Authors
Leonardo Salmena، نويسنده , , Arkaitz Carracedo، نويسنده , , Pier Paolo Pandolfi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
12
From page
403
To page
414
Abstract
Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23 locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor types. A decade of work has established that PTEN is a nonredundant phosphatase that is essential for regulating the highly oncogenic prosurvival PI3K/AKT signaling pathway. This review discusses emerging modes of PTEN function and regulation, and speculates about how manipulation of PTEN function could be used for cancer therapy.
Journal title
CELL
Serial Year
2008
Journal title
CELL
Record number
1019224
Link To Document