• Title of article

    Collateral Damage from Antigen Receptor Gene Diversification

  • Author/Authors

    Grace K. Mahowald، نويسنده , , Jason M. Baron، نويسنده , , Barry P. Sleckman، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2008
  • Pages
    4
  • From page
    1009
  • To page
    1012
  • Abstract
    Chromosomal translocations that juxtapose antigen receptor genes and oncogenes are frequently associated with lymphoid malignancies. In this issue, show that activation-induced deaminase (AID), an enzyme involved in antigen receptor gene diversification, generates DNA double-strand breaks (DSBs) in oncogenes, and propose that AID and the recombinase-activating gene (RAG) endonuclease may collaborate to generate off-target DSBs.
  • Journal title
    CELL
  • Serial Year
    2008
  • Journal title
    CELL
  • Record number

    1019534

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1019534