Title of article
Bridging Physiology and Pathology in AD
Author/Authors
Dohoon Kim، نويسنده , , Li-Huei Tsai، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
997
To page
1000
Abstract
The APP-processing pathway is a pathological component of Alzheimerʹs disease (AD), but there is no consensus regarding the physiological functions of APP and its products. Two studies () link the physiological and pathological aspects of APP processing. They show that the APP products, N-APP and Aβ42, are ligands for death receptor 6 and cellular prion protein, respectively, which are important in nervous system development and synaptic suppression.
Journal title
CELL
Serial Year
2009
Journal title
CELL
Record number
1019784
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