• Title of article

    Disorder, Promiscuity, and Toxic Partnerships

  • Author/Authors

    Edward M. Marcotte، نويسنده , , Mark Tsechansky، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2009
  • Pages
    3
  • From page
    16
  • To page
    18
  • Abstract
    Many genes are toxic when overexpressed, but general mechanisms for this toxicity have proven elusive. find that intrinsic protein disorder and promiscuous molecular interactions are strong determinants of dosage sensitivity, explaining in part the toxicity of dosage-sensitive oncogenes in mice and humans.
  • Journal title
    CELL
  • Serial Year
    2009
  • Journal title
    CELL
  • Record number

    1019822

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1019822