Another Tie that Binds the MTA Family to Breast Cancer

In this issue of Cell, demonstrate that MTA3 is an estrogen-dependent component of the NuRD complex and identify the Snail gene as its direct target. ER signaling upregulates MTA3 levels to negatively modulate Snail-mediated repression of E-cadherin. These findings may explain how ER status controls epithelial-to-mesenchymal transition in human breast tumors.