Author/Authors :
Lakshmi Srinivasan، نويسنده , , Yoshiteru Sasaki، نويسنده , , Dinis Pedro Calado، نويسنده , , Baochun Zhang، نويسنده , , Ji-Hye Paik، نويسنده , , Ronald A. DePinho، نويسنده , , Jeffrey L. Kutok، نويسنده , , John F. Kearney، نويسنده , , Kevin L. Otipoby، نويسنده , , Klaus Rajewsky، نويسنده ,
Abstract :
Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role.
