Fyn-Tau-Amyloid: A Toxic Triad

The axonal protein tau and amyloid β-peptide (Aβ) are key players in the pathogenesis of Alzheimerʹs disease, and tau mediates Aβ toxicity, but it is not clear how. now report an unexpected physiological function for tau in neuronal dendrites that may explain how tau mediates Aβ; toxicity.