Genome-wide “Re”-Modeling of Nucleosome Positions

Two recent studies mapped nucleosomes across the yeast and human genomes, teasing apart the relative contributions of DNA sequence and chromatin remodelers to nucleosome organization. These data suggest two emerging models: chromatin remodelers position nucleosomes around transcriptional start sites in yeast, and a few “locked” nucleosomes may serve as barriers from which nucleosome arrays emanate in human genomes.