Title of article :
NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function
Author/Authors :
Hiroyasu Yamamoto، نويسنده , , Evan G. Williams، نويسنده , , Laurent Mouchiroud، نويسنده , , Carles Cant?، نويسنده , , Weiwei Fan، نويسنده , , Michael Downes، نويسنده , , Christophe Héligon، نويسنده , , Grant D. Barish، نويسنده , , Béatrice Desvergne، نويسنده , , Ronald M. Evans، نويسنده , , Kristina Schoonjans، نويسنده , , Johan Auwerx، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Pages :
13
From page :
827
To page :
839
Abstract :
Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We show here that muscle-specific loss of nuclear receptor corepressor 1 (NCoR1) in mice leads to enhanced exercise endurance due to an increase of both muscle mass and of mitochondrial number and activity. The activation of selected transcription factors that control muscle function, such as MEF2, PPARβ/δ, and ERRs, underpins these phenotypic alterations. NCoR1 levels are decreased in conditions that require fat oxidation, resetting transcriptional programs to boost oxidative metabolism. Knockdown of gei-8, the sole C. elegans NCoR homolog, also robustly increased muscle mitochondria and respiration, suggesting conservation of NCoR1 function. Collectively, our data suggest that NCoR1 plays an adaptive role in muscle physiology and that interference with NCoR1 action could be used to improve muscle function.
Journal title :
CELL
Serial Year :
2011
Journal title :
CELL
Record number :
1020919
Link To Document :
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