Title of article :
DNA-Damage-Induced Differentiation in Hematopoietic Stem Cells
Author/Authors :
Pankaj K. Mandal، نويسنده , , Derrick J. Rossi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
Aging of hematopoietic stem cells (HSCs) is accompanied by diminished functional potential. Wang et al. now provide evidence for an HSC-specific differentiation checkpoint mediated by the transcription factor BATF, which limits self-renewal of HSCs in response to the accumulation of DNA damage.
