Author/Authors :
Li Ye، نويسنده , , Sandra Kleiner، نويسنده , , Jun Wu، نويسنده , , Rajan Sah، نويسنده , , Rana K. Gupta، نويسنده , , Alexander S. Banks، نويسنده , , Paul Cohen، نويسنده , , Melin J. Khandekar، نويسنده , , Pontus Bostr?m، نويسنده , , Rina J. Mepani، نويسنده , , Dina Laznik، نويسنده , , Theodore M. Kamenecka، نويسنده , , Xinyi Song، نويسنده , , Wolfgang Liedtke، نويسنده , , Vamsi K. Mootha، نويسنده , , Pere Puigserver، نويسنده , , Kendall W. Nettles and Patrick R. Griffin، نويسنده , , David E. Clapham، نويسنده , , Bruce M. Spiegelman، نويسنده ,
Abstract :
PGC1α is a key transcriptional coregulator of oxidative metabolism and thermogenesis. Through a high-throughput chemical screen, we found that molecules antagonizing the TRPVs (transient receptor potential vanilloid), a family of ion channels, induced PGC1α expression in adipocytes. In particular, TRPV4 negatively regulated the expression of PGC1α, UCP1, and cellular respiration. Additionally, it potently controlled the expression of multiple proinflammatory genes involved in the development of insulin resistance. Mice with a null mutation for TRPV4 or wild-type mice treated with a TRPV4 antagonist showed elevated thermogenesis in adipose tissues and were protected from diet-induced obesity, adipose inflammation, and insulin resistance. This role of TRPV4 as a cell-autonomous mediator for both the thermogenic and proinflammatory programs in adipocytes could offer a target for treating obesity and related metabolic diseases.
