Title of article
A Mediator Lost in the War on Cancer
Author/Authors
Xing Guo، نويسنده , , Xiao-Fan Wang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
927
To page
929
Abstract
An unexpected role for a Mediator subunit, MED12, in resistance to multiple anticancer agents is revealed by Huang et al. Loss of MED12 confers drug resistance by activating transforming growth factor β (TGF-β) signaling. Inhibition of the TGF-β pathway resensitizes cells to therapeutic drugs, suggesting a new combinatorial cancer treatment.
Journal title
CELL
Serial Year
2012
Journal title
CELL
Record number
1021448
Link To Document