Title of article :
Bacterial Nitric Oxide Extends the Lifespan of C. elegans
Author/Authors :
Ivan Gusarov، نويسنده , , Laurent Gautier، نويسنده , , Olga Smolentseva، نويسنده , , Ilya Shamovsky، نويسنده , , Svetlana Eremina، نويسنده , , Alexander Mironov، نويسنده , , Evgeny Nudler، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Pages :
13
From page :
818
To page :
830
Abstract :
Nitric oxide (NO) is an important signaling molecule in multicellular organisms. Most animals produce NO from L-arginine via a family of dedicated enzymes known as NO synthases (NOSes). A rare exception is the roundworm Caenorhabditis elegans, which lacks its own NOS. However, in its natural environment, C. elegans feeds on Bacilli that possess functional NOS. Here, we demonstrate that bacterially derived NO enhances C. elegans longevity and stress resistance via a defined group of genes that function under the dual control of HSF-1 and DAF-16 transcription factors. Our work provides an example of interspecies signaling by a small molecule and illustrates the lifelong value of commensal bacteria to their host.
Journal title :
CELL
Serial Year :
2013
Journal title :
CELL
Record number :
1021582
Link To Document :
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