Title of article
Pyruvate as a Pivot Point for Oncogene-Induced Senescence
Author/Authors
Benjamin A. Olenchock، نويسنده , , Matthew G. Vander Heiden، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
2
From page
1429
To page
1430
Abstract
Regulation of pyruvate fate is an important determinant of anabolic versus catabolic metabolism. A new report in the journal Nature by Kaplon et al. suggests that driving pyruvate oxidation can thwart tumor growth in BRAF-driven melanoma by inducing oncogene-induced senescence, a finding that might be exploited therapeutically.
Journal title
CELL
Serial Year
2013
Journal title
CELL
Record number
1021762
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