Title of article
Probing DNA by 2-OG-Dependent Dioxygenase
Author/Authors
Chi-Lin Tsai، نويسنده , , Karl-Peter Hopfner and John A. Tainer، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
1448
To page
1450
Abstract
TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation.
Journal title
CELL
Serial Year
2013
Journal title
CELL
Record number
1022042
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