Title of article :
An ecient method for the catalyst-free one-pot green synthesis of 2,4,5-trisubstituted imidazoles in water
Author/Authors :
Dehghan Khalili، Sh. نويسنده Assistant Professor of Organic Chemistry in the Department of Chemistry at the Najafabad Branch of the Islamic Azad University, Isfahan , , Banitaba، S.H. نويسنده Assistant Professor of Organic Chemistry in the Department of Chemistry at the Majlesi Branch of the Islamic Azad University, Isfahan , , Safari، J. نويسنده ,
Issue Information :
دوفصلنامه با شماره پیاپی C2 سال 2013
Abstract :
A mild, ecient and environmentally friendly method has been developed
for the green synthesis of 2,4,5-trisubstituted imidazoles via a three-component one-pot
condensation of 1,2-diketones, diammonium hydrogen phosphate, (NH4)2HPO4 (DAHP)
and aryl aldehydes in water under re
ux conditions. The DAHP shows remarkable activities
for the synthesis of title compounds. The key advantages of this method over conventional
methods are experimental simplicity, good functional group tolerance, excellent yields,
short routine, and selectivity, without the need for a transition metal or base catalyst.
Journal title :
Scientia Iranica(Transactions C: chemistry, chemical engineering)
Journal title :
Scientia Iranica(Transactions C: chemistry, chemical engineering)
