Pharmaceutical applications of a flurbiprofen sensor

The construction and the performance characteristics of an ion-selective PVC membrane electrode for flurbiprofen are described. The electrode, based on the ion-pair complex with Aliquot 336S (tricaprylmethylammonium chloride) cation shows near-Nernstian response in the concentration range 10−2−7 × 10−5 M. Its selectivity relative to various organic and inorganic anions is reported. Potentiometric methods are used to determine the active component flurbiprofen in pharmaceutical preparations. It was applied to the determination of the dissolution profile of FROBEN® tablets.