Control of Transcription through Intragenic Patterns of Nucleosome Composition

Several recent papers show that differences in histone modification and the use of histone variants at the 5ʹ and 3ʹ ends of genes influence the location and kinetics of transcriptional initiation. The ultimate target of most epigenetic mechanisms may be the regulation of nucleosome occupancy, which in turn controls access to DNA at specific genomic locations.