Determination of benzhexol hydrochloride and ethambutol hydrochloride tablets by liquid chromatography

A cyano-bonded phase column together with indirect conductivity detection are used for the liquid Chromatographic determination of the basic drugs benzhexol hydrochloride and ethambutol hydrochloride in tablets as alternatives to existing pharmacopoeia methods. Optimisation of the experimental conditions, linear detection range, and precision of the proposed method have been studied. The results by the proposed method were checked against pharmacopoeia methods. The method is successfully applied to analyse different brands of commercially available tablets. Problems encountered in the determination of these drugs by pharmacopoeia methods are discussed.