Investigation of sources of variance which contribute to NIR-spectroscopic measurement of pharmaceutical formulations

The goal of this study is to improve NIR-spectroscopic measurement of pharmaceutical formulations. The variance contributions of the following factors to the NIR-measurement of tablets, hard and soft gelatine capsules are estimated: measurement repeatability, positioning, time, different samples of one batch and different batches. The data analysis is performed on the one hand with PCA (Principal Component Analysis) as a display method and on the other hand numerically with a nested ANOVA design.