Adsorptive Stripping Voltammetric Behavior and Determination of Zolmitriptan Using Differential Pulse and Square Wave Voltammetry

The oxidative behaviour of zolmitriptan was studied at a glassy carbon electrode in Britton-Robinson (BR) buffer solutions using cyclic, differential pulse and square wave voltammetric techniques. The oxidation process was shown to be irreversible over the pH range (2.0-6.0) and was diffusion controlled with some adsorption character. The analytical method was developed for the determination of zolmitriptan in BR buffer solution at pH 2.0 as supporting electrolyte. The anodic peak current varied linearly with zolmitriptan concentration in the following ranges: 4.0×10-8 to 3.2×10-7 M and 4.0×10-10 to 3.2×10-9 M of zolmitriptan with limits of detection of 2.0×10-8 M and 2.0×10-10 M by differential pulse and square wave methods, respectively. Validation parameters, such as sensitivity, accuracy, precision and recovery were evaluated. The proposed method was applied to the determination of zolmitriptan in the tablet dosage form. The results were compared with those obtained by the reported methods showing higher sensitivity of our proposed method.