Author/Authors :
Babaei، Ali نويسنده Department of Chemistry, Arak University, Arak, P.O. Box 38156-8-8349, Iran , , Farshbaf، Mojtaba نويسنده Department of Chemistry, Arak University, Arak, P.O. Box 38156-8-8349, Iran , , Afrasiabi، Mohammad نويسنده Young Researchers Club, Islamic Azad University, Shoushtar Branch, Shoushtar, Iran , , Bamdad، Farzad نويسنده Department of Chemistry, Arak University, Arak, P.O. Box 38156-8-8349, Iran , , Dehdashti، Aliyeh نويسنده Department of Chemistry, Arak University, Arak, P.O. Box 38156-8-8349, Iran ,
Abstract :
A chemically modified electrode is constructed based on multi-walled carbon
nanotube modified glassy carbon electrode (MWCNTs/GCE) for simultaneous determination
of acetaminophen (ACT) and tryptophan (TRY). The measurements were carried out by
application of differential pulse voltammetry (DPV), cyclic voltammetry (CV) and
chronoamperometry (CA) methods. Application of DPV method showed that the linear
relationship between oxidation peak current and concentration of ACT and TRY were in the
range of 2 ?M to 360 ?M, and 3 ?M to 360 ?M, respectively. Under optimal conditions the
modified electrode exhibited high sensitivity and stability for both ACT and TRY
determination, making it a suitable sensor for the simultaneous submicromolar detection of
ACT and TRY in solutions. The analytical performance of modified electrode has been
evaluated for detection of ACT and TRY in human serum and human urine with satisfactory
results.
