Maximum entropy chromatogram reconstruction Original Research Article

Maximum entropy has been successfully applied to problems of optical images and NMR spectroscopy. In this paper, we present the results of maximum entropy deconvolution applied to simulated and real chromatographic data. A brief theoretical discussion is given. The technique is tested both qualitatively and quantitatively using simulated data. Peak resolution can be dramatically improved but quantitative accuracy is limited. The technique is applied to a re-analysis of Pioneer Venus chromatographic data and to storage column data.