4,4′-Dinitrocarbanilide – hapten development utilizing molecular models Original Research Article

Molecular modeling studies show differences in structural configuration and electrostatic potential isosurfaces that may explain why antibodies produced to a hydrazone derivative of 4,4′-dinitrocarbanilide (DNC) did not compete for DNC. Based on molecular models, haptens are suggested that appear to be adequate DNC-mimics for an immunogen and plate-coating antigen.