Author/Authors :
Neeraj Kumar، نويسنده , , Mahesh Krishnan، نويسنده , , Tony Azzam، نويسنده , , Amir Magora، نويسنده , , Majeti N.V Ravikumar، نويسنده , , Douglas R Flanagan، نويسنده , , Abraham J. Domb، نويسنده ,
Abstract :
Acid anhydrides are considered as important reagents in organic and peptide synthesis and in recent years for the formation of prodrugs and biomaterials for controlled release of drugs. This article highlights the analysis of mixed anhydrides and polyanhydrides synthesized by various methods. Analytical methods including HPLC, GLC, 1H NMR and IR spectroscopy are described for the determination of anhydride hydrolysis and amidation.
Keywords :
Mixed anhydride , Anhydride analysis , Prodrug , Anhydride , Hydrolytic degradation
