Biopartitioning micellar chromatography to predict ecotoxicity Original Research Article

The knowledge of chemical toxicity is necessary for risk assessment and ranking of chemicals according their hazard potential. The use of biopartitioning micellar chromatography has proven to be valid in predicting several biological activities of different kinds of compounds. In this paper, the relationships between retention of 66 organic pollutants and several ecotoxicity parameters are studied. Adequate correlations retention-ecotoxicity (LC50 in fish and daphnia, EC50 in green algae and daphnia, values of chronic toxicity in fish and green algae and bioconcentration factor in fish) of organic pollutants are obtained. These models are compared with the corresponding obtained using apparent log P values of the solutes as independent variables. The QRAR models developed in this paper may be a useful approach to screening new chemicals and in the early stage of development and selection of safer chemicals.