Synergistic effects of mixed GC stationary phase consisting of two different cyclodextrin derivatives Original Research Article

Two cyclodextrin derivatives, permethylated-β-CD and heptakis(2,6-di-O-pentyl-3-O-trifluoroacetyl)-β-CD, were mixed as CGC stationary phase to investigate synergistic effects. The results showed that synergistic effects existed on the mixed stationary phases of two CD derivatives and the biggest synergistic effect was observed on the 2:1 mixed stationary phase of permethylated-β-CD and heptakis(2,6-di-O-pentyl-3-O-trifluoroacetyl)-β-CD. Not only the properties of CD derivatives, but also the size and properties of solutes and the interaction mode between CD derivatives and solutes contributed to the occurring synergistic effect. The steric fitness between two CDs and solute is the main cause for the occurring of synergistic effects.