Separation of β-adrenolytics derived from 4-hydroxyacetophenone by capillary electrophoresis in the presence of cyclodextrins Original Research Article

β-Adrenolytics, derivatives of 4-(3-isobutylamino-2-hydroxypropoxy)-3-alkoxymethyl)acetophenone, synthesized from 4-hydroxyacetophenone and their enantiomers were separated by CE in presence of cyclodextrins or maltodextrin. Addition of maltodextrin into background electrolyte enhanced the efficiency of separation without chiral discrimination. The best separation of enantiomers of studied compounds was observed in presence of carboxymethylated β-cyclodextrin. Migration time of studied compounds was correlated with a set of parameters (log P, dipole moment, molecular volume) calculated by methods of molecular modeling.