Title of article
Development and validation of chemometrics-assisted spectrophotometry and micellar electrokinetic chromatography for the determination of four-component pharmaceuticals Original Research Article
Author/Authors
Alberto J Nepote، نويسنده , , Luciana Vera-Candiotti، نويسنده , , Mar??a R Williner، نويسنده , , Patricia C Damiani، نويسنده , , Alejandro C. Olivieri، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
8
From page
77
To page
84
Abstract
Two methods were developed for the simultaneous determination of the corticosteroid dexamethasone sodium phosphate (DEX), the Vitamins B6 and B12 and the anti-inflammatory piroxicam (PIR) in pharmaceutical tablets. Chemometrics-assisted spectrophotometry based on partial least-squares (PLS-1) regression of UV-Vis spectra and micellar electrokinetic capillary chromatography (MEKC) were satisfactory applied to synthetic samples and to several commercial pharmaceuticals. Both described methodologies avoid preliminary sample separation steps. The results were statistically comparable to the reference high performance liquid chromatography method (HPLC).
Keywords
Spectrophotometry , Micellar electrokinetic chromatography , Dexamethasone , Piroxicam , Multivariate calibration , Vitamins B6/B12
Journal title
Analytica Chimica Acta
Serial Year
2003
Journal title
Analytica Chimica Acta
Record number
1033632
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