Author/Authors :
Kumar Bagri، Puneet نويسنده Dept. of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India , , Singhal، Mukesh Kumar نويسنده Dept. of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India , , Singh، Daleep نويسنده Dept. of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India , , Kapoor، Akhil نويسنده Dept. of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India , , Jakhar، Shankar Lal نويسنده Dept. of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India , , Sharma، Neeti نويسنده Dept. of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India , , Beniwal، Surender نويسنده Medical Oncology section, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India , , Kumar، Harvindra Singh نويسنده Dept. of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India , , Sharma، Ajay نويسنده Dept. of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India , , Bardia، Megh Raj نويسنده Dept. of Radiatiation Oncology, Acharya tulsi Regional Cancer Treatment and Research Institute, Bikaner, Rajasthan University of Health Sciences, Jai ,
Abstract :
Background: This prospective study was conducted to evaluate and compare the efficacies of nasopharyngoscopy and CT scan in the diagnosis of local failure of external beam radiotherapy (EBRT) for nasopharyngeal carcinoma.
Methods: Total 52 patients of histopathologically proven nasopharyngeal carcinoma treated with external beam radiotherapy (EBRT), were included in this study. For every patient computed tomography (CT), nasopharyngoscopy and nasopharyngeal biopsies were performed 3 months after completion of EBRT.
Results: Three months after completion of EBRT, 9 patients (17.3%) had evident disease on histological examination of biopsies. Nasopharyngoscopy showed 77.78% sensitivity, 93.03% specificity, 70% positive predictive value and 95.24% negative predictive value in diagnosing the residual/recurrence of tumor. There was statistically significant agreement between the endoscopic findings and the histological findings (Kappa reliability coefficient=0.562, p < 0.01). On the other hand, CT scan showed a 55.56% sensitivity, 39.53% specificity, 16.13% positive predictive value and 80.95% negative predictive value in diagnosing the residual tumor/recurrence. There was no statistically significant agreement between the CT scan findings and the histological findings (Kappa reliability coefficient = 0.038, p > 0.05).
Conclusion: Nasopharyngoscopy should be considered the primary follow-up tool after radiotherapy of nasopharyngeal carcinoma. CT scan should be reserved for patients with histological or any symptomatic indications. Routine postnasal biopsies are not required.
