Title of article :
Analysis of time-dependent conjugation of gold nanoparticles with an antiparkinsonian molecule by using curve resolution methods Original Research Article
Author/Authors :
José Manuel Amigo، نويسنده , , Neus G. Bast?s، نويسنده , , Rob Hoen، نويسنده , , Socorro V?zquez-Campos، نويسنده , , Miriam Var?n، نويسنده , , Miriam Royo and Maria J. Macias، نويسنده , , Victor Puntes، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Abstract :
In this work, the time-dependent conjugation process between a thiolated molecule (with anti-parkinsonian properties) and gold nanoparticles has been monitored and studied by the combined use of fast acquisition Ultra Violet–Visible (UV–Vis) spectra and the ability of Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) technique. From the highly informative kinetic profiles obtained it was possible to extract quantitative and qualitative information of the conjugation process which includes i) time-dependent concentration profiles and pure spectra of species involved on conjugation process, ii) estimation of molecule concentration necessary for the completeness of the conjugation reaction, iii) molecule footprint and iv) free energy of molecule adsorption.
Keywords :
Ultra Violet–Visible spectroscopy , Kinetic modeling , Multivariate Curve Resolution-Alternating Least Squares , Gold nanoparticles , Adenosine antagonist
Journal title :
Analytica Chimica Acta
Journal title :
Analytica Chimica Acta