Author/Authors :
Khaksar، Zabiholla نويسنده Department of Basic sciences, School of Veterinary Medicine, ShirazUniversity, Shiraz, Iran , , Jelodar، Gholamali نويسنده Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Jelodar, Gholamali , Hematian، Hooman نويسنده Department of Veterinary sciences, Yasooj Branch, Islamic Azad University, Yasooj, Iran , , Poorahmadi، Mohamad نويسنده Department of Basic Sciences, Jahrom medical university, Jahrom, Iran ,
Abstract :
In pregnant mothers, maternal diabetes occurs when the pancreas cannot produce enough insulin, which leads to
increased blood glucose concentration in the motherand consequently in the foetus, causing various neonatal
problems. This study was conducted to evaluate the effects of maternal diabetes on foetal ovarian structure. Sixteen
adult female rats were allocated into two equal groups. Diabetes was induced in one group by alloxan agent. Both
groups became pregnant by natural mating. 60 days after birth, the female offspring were terminated, the body
weight and blood glucose of the animals measured and their ovaries removed. Various histological parameters were
determined using histological techniques. Results revealed a significant increase in body weight and blood glucose
in the offspring of the diabetic mothers (ODM) compared to that of controls. The weight, volume and diameter of
the ovary and ovarian capsule thickness were decreased in the ODM group. The number and diameter of primary,
preantral, antral and preovulatory follicles and corpora lutea were decreased in ovaries in the ODM. Maternal
hyperglycaemia exhibited deleterious effects on thereproductive system of their offspring.
