An animal study of a novel tri-layer wound dressing material — non-woven fabric grafted with N-isopropyl acrylamide and gelatin

A novel method of preparation of easily stripped-off temporary wound dressing material is described. A tri-layer membrane system for artificial skin is prepared in this study. In this process, the N-isopropyl acrylamide monomer is successfully grafted on the non-woven fabric by co-polymerization. It is initiated by plasma to activate the surface of the non-woven cloth. N-isopropyl acrylamide is then grafted onto the surface of the non-woven cloth by γ-ray irradiation. The last, but the most important, layer of a bovine gelatin with glycosaminoglycans (chondroitin-6-sulfate) is grafted by UV light, which serves as a matrix for the infiltration of fibroblasts, macrophages, lymphocytes, and capillaries derived from the wound bed.